What is recorded here?
Defined ferroptosis as an iron-dependent, oxidative and nonapoptotic form of cell death induced in the studied systems by erastin and inhibited by ferrostatin-1.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact 12-author 2012 Cell paper. Its cancer-cell and organotypic-slice experiments do not establish ferroptosis as the mechanism of every pathological cell death or prove clinical benefit from inducing or inhibiting it; later GPX4 and disease studies remain separate.
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People and systems
Scott J. Dixon; Kathryn M. Lemberg; Michael R. Lamprecht; Rachid Skouta; Eleina M. Zaitsev; Caroline E. Gleason; Darpan N. Patel; Andras J. Bauer; Alexandra M. Cantley; Wan Seok Yang; Barclay Morrison III; Brent R. Stockwell
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
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Documented countries / regions: United States
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English catalogue narrative
Dixon and colleagues: ferroptosis as iron-dependent cell death
Defined ferroptosis as an iron-dependent, oxidative and nonapoptotic form of cell death induced in the studied systems by erastin and inhibited by ferrostatin-1.
Scientific scope
The record is the exact 12-author 2012 Cell paper. Its cancer-cell and organotypic-slice experiments do not establish ferroptosis as the mechanism of every pathological cell death or prove clinical benefit from inducing or inhibiting it; later GPX4 and disease studies remain separate.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Scott J. Dixon; Kathryn M. Lemberg; Michael R. Lamprecht; Rachid Skouta; Eleina M. Zaitsev; Caroline E. Gleason; Darpan N. Patel; Andras J. Bauer; Alexandra M. Cantley; Wan Seok Yang; Barclay Morrison III; Brent R. Stockwell
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.