Dixon and colleagues: ferroptosis as iron-dependent cell death

What changed

Characterized iron-dependent nonapoptotic cell death and ferrostatin-sensitive oxidative mechanism.

Scientific scope

The record is the exact 12-author 2012 Cell paper. Its cancer-cell and organotypic-slice experiments do not establish ferroptosis as the mechanism of every pathological cell death or prove clinical benefit from inducing or inhibiting it; later GPX4 and disease studies remain separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 12-author 2012 Cell paper. Its cancer-cell and organotypic-slice experiments do not establish ferroptosis as the mechanism of every pathological cell death or prove clinical benefit from inducing or inhibiting it; later GPX4 and disease studies remain separate.

Contributors

• The named authors listed in the linked research record · SCIENCE: Complete source byline retained in the research record; this collective display does not merge person identities or measure labor shares.

• PubMed record for the ferroptosis paper
• PMC full text of the ferroptosis paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

Full scientific record · Browse contribution grades · Request a correction