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Its cancer-cell and organotypic-slice experiments do not establish ferroptosis as the mechanism of every pathological cell death or prove clinical benefit from inducing or inhibiting it; later GPX4 and disease studies remain separate.", "domain": "Anatomy, physiology and pathology" }, "sources": [ { "citation": "PubMed record for the ferroptosis paper", "url": "https://pubmed.ncbi.nlm.nih.gov/22632970/" }, { "citation": "PMC full text of the ferroptosis paper", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3367386/" } ], "statement": "# Dixon and colleagues: ferroptosis as iron-dependent cell death\n\nDefined ferroptosis as an iron-dependent, oxidative and nonapoptotic form of cell death induced in the studied systems by erastin and inhibited by ferrostatin-1.\n\n## Scientific scope\n\nThe record is the exact 12-author 2012 Cell paper. Its cancer-cell and organotypic-slice experiments do not establish ferroptosis as the mechanism of every pathological cell death or prove clinical benefit from inducing or inhibiting it; later GPX4 and disease studies remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nScott J. Dixon; Kathryn M. Lemberg; Michael R. Lamprecht; Rachid Skouta; Eleina M. Zaitsev; Caroline E. Gleason; Darpan N. Patel; Andras J. Bauer; Alexandra M. Cantley; Wan Seok Yang; Barclay Morrison III; Brent R. Stockwell\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [PubMed record for the ferroptosis paper](https://pubmed.ncbi.nlm.nih.gov/22632970/)\n- [PMC full text of the ferroptosis paper](https://pmc.ncbi.nlm.nih.gov/articles/PMC3367386/)\n", "summary": "Defined ferroptosis as an iron-dependent, oxidative and nonapoptotic form of cell death induced in the studied systems by erastin and inhibited by ferrostatin-1.", "title": "Dixon and colleagues: ferroptosis as iron-dependent cell death" }, "record_id": "urn:uuid:c9c666ba-ceb1-4e87-af85-14a0e7686e12", "version": 1, "source_ref": { "record_id": "urn:uuid:c9c666ba-ceb1-4e87-af85-14a0e7686e12", "version": 1, "content_hash": "sha256:8f1391f6b5c15bb520f836beb9dcb9c96fc665ba017108d5cc7d56ad7d3c2c9d" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:c2d9ee91ce38b19d6b259e4af69feecf7011152f0b40aab6c536bb85448e776d" }, "target": { "record_id": "urn:uuid:c9c666ba-ceb1-4e87-af85-14a0e7686e12", "version": 1, "content_hash": "sha256:8f1391f6b5c15bb520f836beb9dcb9c96fc665ba017108d5cc7d56ad7d3c2c9d" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "dixon-et-al-ferroptosis-2012", "entry_id": "dixon-et-al-ferroptosis-2012", "revision": 1, "title": "Dixon and colleagues: ferroptosis as iron-dependent cell death", "context": "Cell biology", "track": "EXPERIMENT", "band": "A", "modifier": "+", "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-25", "evidence_cutoff": "2026-09-25", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "Characterized iron-dependent nonapoptotic cell death and ferrostatin-sensitive oxidative mechanism.", "scope": "The record is the exact 12-author 2012 Cell paper. 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