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Till and McCulloch: direct assay of proliferating bone-marrow cells

Contribution grade

Transplantation and regenerative medicine · METHOD

Reference score125,000Provisional editorial estimate of this exact contribution; its grade is assessed separately.

What changed

Introduced mouse spleen-colony readout for proliferative marrow cells and radiation sensitivity.

Scientific scope

The record is the exact two-author 1961 Radiation Research paper. Its direct observations concern irradiated mice and colony-forming cells; later interpretation as foundational stem-cell evidence, self-renewal experiments and human clinical transplantation remain distinct.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact two-author 1961 Radiation Research paper. Its direct observations concern irradiated mice and colony-forming cells; later interpretation as foundational stem-cell evidence, self-renewal experiments and human clinical transplantation remain distinct.

Contributors

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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