Sato and colleagues: single Lgr5 stem cells form crypt-villus organoids

What changed

Established long-term self-organization of mouse intestinal epithelium from one Lgr5+ stem cell without mesenchymal niche.

Scientific scope

The record is the exact 2009 Nature paper using mouse intestinal cells. Earlier three-dimensional cultures, later human organoids, disease models, transplantation, drug testing and clinical efficacy claims remain separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 2009 Nature paper using mouse intestinal cells. Earlier three-dimensional cultures, later human organoids, disease models, transplantation, drug testing and clinical efficacy claims remain separate.

Contributors

• The named authors listed in the linked research record · SCIENCE: Complete source byline retained in the research record; this collective display does not merge person identities or measure labor shares.

• Hubrecht Institute copy of Sato organoid paper
• PubMed record for Sato organoid paper

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