AWhat changed
Showed that double-stranded RNA could strongly and specifically interfere with gene expression in C. elegans.
Scientific scope
Showed that double-stranded RNA could strongly and specifically interfere with gene expression in C. elegans. Scope limitation: The mechanism and organism in this paper are distinguished from subsequent therapeutic delivery systems and drug approvals.
Evidence
Assessment uses the catalogue-linked source evidence for the stated contribution. The mechanism and organism in this paper are distinguished from subsequent therapeutic delivery systems and drug approvals.
Contributors
- Andrew Fire · SCIENCE: Named source contributor; exact labor shares are not measured.
- SiQun Xu · SCIENCE: Named source contributor; exact labor shares are not measured.
- Mary K. Montgomery · SCIENCE: Named source contributor; exact labor shares are not measured.
- Steven A. Kostas · SCIENCE: Named source contributor; exact labor shares are not measured.
- Samuel E. Driver · SCIENCE: Named source contributor; exact labor shares are not measured.
- Craig C. Mello · SCIENCE: Named source contributor; exact labor shares are not measured.
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans — deposited bibliography
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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