Nowell and Hungerford: a minute chromosome in chronic granulocytic leukemia

What changed

Reported a recurrent minute chromosome in seven chronic-granulocytic-leukemia cases and suggested disease relevance.

Scientific scope

The record is the exact two-author 1960 Science abstract. It documents the recurrent cytogenetic observation, not the later identification of chromosomes 9 and 22, the BCR-ABL fusion, tyrosine-kinase mechanism or targeted therapy.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact two-author 1960 Science abstract. It documents the recurrent cytogenetic observation, not the later identification of chromosomes 9 and 22, the BCR-ABL fusion, tyrosine-kinase mechanism or targeted therapy.

Contributors

• Peter C. Nowell · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• David A. Hungerford · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• Peter Nowell retrospective on the minute-chromosome abstract
• Haematologica landmark review of the Philadelphia chromosome paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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