What is recorded here?
Reported a recurrent minute chromosome in cells from seven patients with chronic granulocytic leukemia and proposed a causal relation to the disease.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact two-author 1960 Science abstract. It documents the recurrent cytogenetic observation, not the later identification of chromosomes 9 and 22, the BCR-ABL fusion, tyrosine-kinase mechanism or targeted therapy.
Read the original work
- Peter Nowell retrospective on the minute-chromosome abstract
- Haematologica landmark review of the Philadelphia chromosome paper
This English explanation is an editorial reading view. It does not replace the complete original work or certify its science.
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People and systems
Peter C. Nowell; David A. Hungerford
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
Research locations and affiliations
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Documented countries / regions: United States
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English catalogue narrative
Nowell and Hungerford: a minute chromosome in chronic granulocytic leukemia
Reported a recurrent minute chromosome in cells from seven patients with chronic granulocytic leukemia and proposed a causal relation to the disease.
Scientific scope
The record is the exact two-author 1960 Science abstract. It documents the recurrent cytogenetic observation, not the later identification of chromosomes 9 and 22, the BCR-ABL fusion, tyrosine-kinase mechanism or targeted therapy.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Peter C. Nowell; David A. Hungerford
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.