Mosmann and colleagues: two types of murine helper T-cell clone

What changed

Distinguished two reproducible cytokine and lymphokine patterns among antigen-specific murine helper T-cell clones.

Scientific scope

The record is the exact five-author 1986 Journal of Immunology paper. It concerns cloned murine helper T cells under the reported assays; it does not establish an exhaustive taxonomy of human T-cell states or absorb later cytokine, lineage and plasticity work.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact five-author 1986 Journal of Immunology paper. It concerns cloned murine helper T cells under the reported assays; it does not establish an exhaustive taxonomy of human T-cell states or absorb later cytokine, lineage and plasticity work.

Contributors

• T. R. Mosmann · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• H. Cherwinski · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• M. W. Bond · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• M. A. Giedlin · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• R. L. Coffman · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for murine helper-T-cell types
• Full text of Mosmann helper-T-cell paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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