Ishida and colleagues: isolation and induced expression of PD-1

What changed

PD-1 became a named molecular object for later functional study.

Scientific scope

Exact four-author 1992 paper, not later immune checkpoint function or therapy.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1992 EMBO Journal paper and its gene-isolation and expression findings. Later identification of PD-1 as an immune inhibitory receptor, PD-L1/PD-L2 biology, checkpoint blockade and clinical cancer therapy remain separate.

Contributors

• Yasumasa Ishida · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Yasutoshi Agata · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Keiichi Shibahara · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Tasuku Honjo · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• Ishida et al., induced expression of PD-1
• Crossref record for Ishida et al. PD-1 paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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