What is recorded here?
Isolated the PD-1 gene by subtractive hybridization and reported its induced expression in selected programmed-cell-death settings, identifying a new immunoglobulin-superfamily member.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact 1992 EMBO Journal paper and its gene-isolation and expression findings. Later identification of PD-1 as an immune inhibitory receptor, PD-L1/PD-L2 biology, checkpoint blockade and clinical cancer therapy remain separate.
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People and systems
Yasumasa Ishida; Yasutoshi Agata; Keiichi Shibahara; Tasuku Honjo
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
Research locations and affiliations
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Documented countries / regions: Japan
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English catalogue narrative
Ishida and colleagues: isolation and induced expression of PD-1
Isolated the PD-1 gene by subtractive hybridization and reported its induced expression in selected programmed-cell-death settings, identifying a new immunoglobulin-superfamily member.
Scientific scope
The record is the exact 1992 EMBO Journal paper and its gene-isolation and expression findings. Later identification of PD-1 as an immune inhibitory receptor, PD-L1/PD-L2 biology, checkpoint blockade and clinical cancer therapy remain separate.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Yasumasa Ishida; Yasutoshi Agata; Keiichi Shibahara; Tasuku Honjo
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.