Hamill and colleagues: giga-seal patch-clamp configurations

What changed

Researchers could record small currents with much lower noise and flexible membrane configurations.

Scientific scope

Five-author 1981 methods article; initial single-channel discovery and later applications separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1981 Pflügers Archiv methods paper. Earlier single-channel recordings, later instrumentation, individual ion-channel discoveries and clinical applications remain separate.

Contributors

• O. P. Hamill · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• A. Marty · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• E. Neher · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• B. Sakmann · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• F. J. Sigworth · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for improved patch-clamp techniques
• Hamill et al. patch-clamp paper copy

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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