AWhat changed
Detected OB protein in plasma and showed recombinant protein reduced weight and intake in selected mice, not db/db mice.
Scientific scope
The record is the exact nine-author 1995 Science mouse study. It does not establish human weight-loss efficacy or safety, and the absence of effect in db/db mice and the separate 1994 gene-cloning work remain explicit boundaries.
Evidence
The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact nine-author 1995 Science mouse study. It does not establish human weight-loss efficacy or safety, and the absence of effect in db/db mice and the separate 1994 gene-cloning work remain explicit boundaries.
Contributors
- Jeffrey L. Halaas · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Karen S. Gajiwala · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Margit Maffei · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Steven L. Cohen · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Brian T. Chait · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Daniel Rabinowitz · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Robert L. Lallone · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Stephen K. Burley · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Jeffrey M. Friedman · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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