What is recorded here?
Detected the OB protein in plasma and showed that recombinant mouse or human protein reduced food intake, body weight and fat in selected mouse models.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact nine-author 1995 Science mouse study. It does not establish human weight-loss efficacy or safety, and the absence of effect in db/db mice and the separate 1994 gene-cloning work remain explicit boundaries.
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People and systems
Jeffrey L. Halaas; Karen S. Gajiwala; Margit Maffei; Steven L. Cohen; Brian T. Chait; Daniel Rabinowitz; Robert L. Lallone; Stephen K. Burley; Jeffrey M. Friedman
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
Research locations and affiliations
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Documented countries / regions: United States
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English catalogue narrative
Halaas and colleagues: weight-reducing effects of the obese-gene protein
Detected the OB protein in plasma and showed that recombinant mouse or human protein reduced food intake, body weight and fat in selected mouse models.
Scientific scope
The record is the exact nine-author 1995 Science mouse study. It does not establish human weight-loss efficacy or safety, and the absence of effect in db/db mice and the separate 1994 gene-cloning work remain explicit boundaries.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Jeffrey L. Halaas; Karen S. Gajiwala; Margit Maffei; Steven L. Cohen; Brian T. Chait; Daniel Rabinowitz; Robert L. Lallone; Stephen K. Burley; Jeffrey M. Friedman
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.