Guthrie and Susi: population newborn screening for phenylketonuria

What changed

Reported a bacterial-inhibition phenylalanine assay suitable for screening large newborn cohorts.

Scientific scope

The record is the exact two-author 1963 Pediatrics paper. It does not absorb dietary treatment, later screening panels, tandem mass spectrometry or claims of perfect sensitivity; timing and false-negative limitations were investigated subsequently.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact two-author 1963 Pediatrics paper. It does not absorb dietary treatment, later screening panels, tandem mass spectrometry or claims of perfect sensitivity; timing and false-negative limitations were investigated subsequently.

Contributors

• Robert Guthrie · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Ada Susi · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for Guthrie-Susi PKU screening

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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