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Furchgott and Zawadzki: endothelial requirement for acetylcholine relaxation

Contribution grade

Cardiovascular and respiratory medicine · EMPIRICAL

Reference score220,000Provisional editorial estimate of this exact contribution; its grade is assessed separately.

What changed

Showed rabbit-vessel relaxation requires intact endothelium and inferred released relaxing substance.

Scientific scope

The record is the exact two-author 1980 Nature experiment in isolated animal vessels. It does not absorb later identification of nitric oxide, human clinical effects, other endothelium-derived factors or all vascular signaling.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact two-author 1980 Nature experiment in isolated animal vessels. It does not absorb later identification of nitric oxide, human clinical effects, other endothelium-derived factors or all vascular signaling.

Contributors

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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