Finlay, Hinds and Levine: wild-type p53 suppresses transformation

What changed

Showed wild-type p53 suppresses oncogene-driven transformation in rat fibroblast assays.

Scientific scope

The record is the exact three-author 1989 Cell paper. Its evidence is an experimental transformation model, not by itself a clinical cancer outcome, and it does not absorb p53 discovery, mutation surveys, later mechanism or therapeutic development.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact three-author 1989 Cell paper. Its evidence is an experimental transformation model, not by itself a clinical cancer outcome, and it does not absorb p53 discovery, mutation surveys, later mechanism or therapeutic development.

Contributors

• Cathy A. Finlay · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Philip W. Hinds · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Arnold J. Levine · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record and abstract for p53 suppressor paper
• Cell DOI for p53 suppressor paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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