What is recorded here?
Showed in primary rat-embryo fibroblast transformation assays that wild-type p53 could inhibit transformation driven by oncogene combinations, while selected transformed foci lost or altered p53 expression.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact three-author 1989 Cell paper. Its evidence is an experimental transformation model, not by itself a clinical cancer outcome, and it does not absorb p53 discovery, mutation surveys, later mechanism or therapeutic development.
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People and systems
Cathy A. Finlay; Philip W. Hinds; Arnold J. Levine
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
Research locations and affiliations
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Documented countries / regions: United States
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English catalogue narrative
Finlay, Hinds and Levine: wild-type p53 suppresses transformation
Showed in primary rat-embryo fibroblast transformation assays that wild-type p53 could inhibit transformation driven by oncogene combinations, while selected transformed foci lost or altered p53 expression.
Scientific scope
The record is the exact three-author 1989 Cell paper. Its evidence is an experimental transformation model, not by itself a clinical cancer outcome, and it does not absorb p53 discovery, mutation surveys, later mechanism or therapeutic development.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Cathy A. Finlay; Philip W. Hinds; Arnold J. Levine
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.