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Domagk: Prontosil against bacterial infection

Contribution grade

Pharmacology and therapeutics · EMPIRICAL

Reference score250,000Provisional editorial estimate of this exact contribution; its grade is assessed separately.

What changed

Reported Prontosil protection in infected mice and other bounded animal observations.

Scientific scope

The record is Domagk's sole-author 1935 German paper and its animal evidence. Chemical synthesis by Josef Klarer and Fritz Mietzsch, subsequent clinical studies, identification of sulfanilamide as the active moiety and later sulfonamides remain separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is Domagk's sole-author 1935 German paper and its animal evidence. Chemical synthesis by Josef Klarer and Fritz Mietzsch, subsequent clinical studies, identification of sulfanilamide as the active moiety and later sulfonamides remain separate.

Contributors

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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