Choo and colleagues: isolation of a cDNA clone from the hepatitis C virus genome

What changed

Isolated a cDNA clone derived from the hepatitis C agent and linked it to antigenic evidence.

Scientific scope

The record is the exact six-author 1989 Science paper. It does not absorb earlier non-A, non-B hepatitis epidemiology, later full-genome work, diagnostic-assay development, treatment trials or the contributions of people not on this target byline.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact six-author 1989 Science paper. It does not absorb earlier non-A, non-B hepatitis epidemiology, later full-genome work, diagnostic-assay development, treatment trials or the contributions of people not on this target byline.

Contributors

• Q. L. Choo · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• G. Kuo · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• A. J. Weiner · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• L. R. Overby · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• D. W. Bradley · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• M. Houghton · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for hepatitis C cDNA paper
• Journal of Hepatology retrospective on hepatitis C discovery

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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