AWhat changed
Validated multiplexed sequencing against karyotyping in high-risk pregnancies, with protocol-dependent performance.
Scientific scope
The record is the exact 24-author 2011 BMJ study in a high-risk population already indicated for invasive testing. Its validation population, archived samples, assay failures and reference standard bound the result; it is not a universal prenatal diagnosis or screening-policy recommendation.
Evidence
The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 24-author 2011 BMJ study in a high-risk population already indicated for invasive testing. Its validation population, archived samples, assay failures and reference standard bound the result; it is not a universal prenatal diagnosis or screening-policy recommendation.
Contributors
- The named authors listed in the linked research record · SCIENCE: Complete source byline retained in the research record; this collective display does not merge person identities or measure labor shares.
- PubMed record for maternal-plasma trisomy-21 sequencing validation
- BMJ full article for maternal-plasma trisomy-21 sequencing validation
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
Full scientific record · Browse contribution grades · Request a correction