What is recorded here?
Evaluated multiplexed maternal-plasma DNA sequencing against fetal karyotyping in a large high-risk validation study for confirming or excluding trisomy 21.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact 24-author 2011 BMJ study in a high-risk population already indicated for invasive testing. Its validation population, archived samples, assay failures and reference standard bound the result; it is not a universal prenatal diagnosis or screening-policy recommendation.
Read the original work
- PubMed record for maternal-plasma trisomy-21 sequencing validation
- BMJ full article for maternal-plasma trisomy-21 sequencing validation
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People and systems
Rossa W. K. Chiu; Ranjit Akolekar; Yama W. L. Zheng; Tak Y. Leung; Hao Sun; K. C. Allen Chan; Fiona M. F. Lun; Attie T. J. I. Go; Elizabeth T. Lau; William W. K. To; Wing C. Leung; Rebecca Y. K. Tang; Sidney K. C. Au-Yeung; Helena Lam; Yu Y. Kung; Xiuqing Zhang; John M. G. van Vugt; Ryoko Minekawa; Mary H. Y. Tang; Jun Wang; Cees B. M. Oudejans; Tze K. Lau; Kypros H. Nicolaides; Y. M. Dennis Lo
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
Research locations and affiliations
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Documented countries / regions: China, United Kingdom, Netherlands
Documented research locations or paper affiliations for this contribution. Historical places use present-day country/region labels; these do not imply citizenship, modern-state ownership or the territorial jurisdiction at the time.
English catalogue narrative
Chiu and colleagues: maternal-plasma sequencing for trisomy 21 assessment
Evaluated multiplexed maternal-plasma DNA sequencing against fetal karyotyping in a large high-risk validation study for confirming or excluding trisomy 21.
Scientific scope
The record is the exact 24-author 2011 BMJ study in a high-risk population already indicated for invasive testing. Its validation population, archived samples, assay failures and reference standard bound the result; it is not a universal prenatal diagnosis or screening-policy recommendation.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Rossa W. K. Chiu; Ranjit Akolekar; Yama W. L. Zheng; Tak Y. Leung; Hao Sun; K. C. Allen Chan; Fiona M. F. Lun; Attie T. J. I. Go; Elizabeth T. Lau; William W. K. To; Wing C. Leung; Rebecca Y. K. Tang; Sidney K. C. Au-Yeung; Helena Lam; Yu Y. Kung; Xiuqing Zhang; John M. G. van Vugt; Ryoko Minekawa; Mary H. Y. Tang; Jun Wang; Cees B. M. Oudejans; Tze K. Lau; Kypros H. Nicolaides; Y. M. Dennis Lo
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.