Calne and colleagues: cyclosporin A in renal allograft recipients

What changed

Demonstrated early renal-allograft clinical promise in seven recipients while documenting serious toxicity.

Scientific scope

The record is the exact nine-author 1978 clinical report in seven recipients. It does not establish modern transplant-regimen efficacy or safety, absorb earlier animal studies or generalize its outcomes to other organs and protocols.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact nine-author 1978 clinical report in seven recipients. It does not establish modern transplant-regimen efficacy or safety, absorb earlier animal studies or generalize its outcomes to other organs and protocols.

Contributors

R. Y. Calne · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
D. J. White · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
S. Thiru · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
D. B. Evans · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
P. McMaster · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
D. C. Dunn · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
G. N. Craddock · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
B. D. Pentlow · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
K. Rolles · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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