RFdiffusion: de novo protein design

Documented mapping · Included in country comparison

Documented countries / regions: United States, France, United Kingdom, South Korea

1 grid.34477.33 0000000122986657 Department of Biochemistry, University of Washington, Seattle, WA USA; 2 grid.34477.33 0000000122986657 Institute for Protein Design, University of Washington, Seattle, WA USA; 3 grid.34477.33 0000000122986657 Graduate Program in Molecular Engineering, University of Washington, Seattle, WA USA; 4 grid.21729.3f 0000000419368729 Columbia University, Department of Statistics, New York, NY USA; 5 grid.21729.3f 0000000419368729 Irving Institute for Cancer Dynamics, Columbia University, New York, NY USA; 6 grid.116068.8 0000 0001 2341 2786 Massachusetts Institute of Technology, Cambridge, MA USA; 7 grid.34477.33 0000000122986657 Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA USA; 8 grid.5607.4 0000 0001 2353 2622 National Centre for Scientific Research, École Normale Supérieure rue d’Ulm, Paris, France; 9 grid.34477.33 0000000122986657 Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA USA; 10 grid.5335.0 0000000121885934 Department of Engineering, University of Cambridge, Cambridge, UK; 11 grid.38142.3c 000000041936754X Faculty of Applied Sciences, Harvard University, Cambridge, MA USA; 12 grid.38142.3c 000000041936754X John Harvard Distinguished Science Fellowship, Harvard University, Cambridge, MA USA; 13 grid.31501.36 0000 0004 0470 5905 School of Biological Sciences, Seoul National University, Seoul, Republic of Korea; 14 grid.34477.33 0000000122986657 Howard Hughes Medical Institute, University of Washington, Seattle, WA USA

• Location evidence

RFdiffusion: de novo protein design

Uses diffusion models to design protein structures and functions, with experimental examples.

Scientific scope

Design predictions and experimental validation remain separate. Do not infer that arbitrary functions can be realized.

Reading status

This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.

People and systems

Joseph Watson; David Juergens; Nathaniel R. Bennett; Brian L. Trippe; Jason Yim; Helen E. Eisenach; Woody Ahern; Andrew J. Borst; Robert J. Ragotte; Lukas F. Milles; Basile I. M. Wicky; Nikita Hanikel; Samuel J. Pellock; Alexis Courbet; William Sheffler; Jue Wang; Preetham Venkatesh; Isaac Sappington; Susana Vázquez Torres; Anna Lauko; Valentin De Bortoli; Emile Mathieu; Sergey Ovchinnikov; Regina Barzilay; Tommi S. Jaakkola; Frank DiMaio; Minkyung Baek; David Baker

Listed source contributors; individual labor shares are not measured

RFdiffusion / University of Washington / RFdiffusion: Research system / execution (source reported).

Original sources

• Watson et al., De novo design of protein structure and function with RFdiffusion (2023)
• Publisher-deposited byline: De novo design of protein structure and function with RFdiffusion