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Allen School of Computer Science and Engineering, University of Washington, Seattle, WA USA; 8 grid.5607.4 0000 0001 2353 2622 National Centre for Scientific Research, École Normale Supérieure rue d’Ulm, Paris, France; 9 grid.34477.33 0000000122986657 Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA USA; 10 grid.5335.0 0000000121885934 Department of Engineering, University of Cambridge, Cambridge, UK; 11 grid.38142.3c 000000041936754X Faculty of Applied Sciences, Harvard University, Cambridge, MA USA; 12 grid.38142.3c 000000041936754X John Harvard Distinguished Science Fellowship, Harvard University, Cambridge, MA USA; 13 grid.31501.36 0000 0004 0470 5905 School of Biological Sciences, Seoul National University, Seoul, Republic of Korea; 14 grid.34477.33 0000000122986657 Howard Hughes Medical Institute, University of Washington, Seattle, WA USA", "source_url": "https://europepmc.org/articles/PMC10468394", "target": { "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "content_hash": "sha256:a44cbc0d766cebccf7e2bfa90d69a2226ca2d59f5f84a3add9428258292e923f" }, "basis": "RESEARCH_LOCATION_OR_PAPER_AFFILIATION", "reviewed_on": "2026-09-12", "nationality_inferred": false, "coverage_status": "COMPLETE", "country_labels": { "US": "United States", "FR": "France", "GB": "United Kingdom", "KR": "South Korea" } }, "points": "60000", "published_grade": { "id": "rfdiffusion", "entry_id": "rfdiffusion", "band": "A", "modifier": null, "target": { "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "content_hash": "sha256:a44cbc0d766cebccf7e2bfa90d69a2226ca2d59f5f84a3add9428258292e923f" }, "what_changed": "Uses diffusion models to design protein structures and functions, with experimental examples.", "scope": "Uses diffusion models to design protein structures and functions, with experimental examples. Scope limitation: Design predictions and experimental validation remain separate. Do not infer that arbitrary functions can be realized.", "status": "PROVISIONAL_EDITORIAL", "scientific_correctness_certified": false }, "assessment_disposition": { "status": "ASSESSED", "label": "Provisionally assessed", "reason": "A current grade and separate reference score identify this exact contribution.", "target": { "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "content_hash": "sha256:a44cbc0d766cebccf7e2bfa90d69a2226ca2d59f5f84a3add9428258292e923f" }, "edition": "ratings-e039106f30dec177" } }, "version": { "kind": "PUBLIC_RECORD_VIEW", "previous": { "content_hash": "sha256:537e6b23794ddce662163e1e5f036ae986384d187077f0dbedc920c7728a3bb9", "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 1 }, "published_at": "2026-09-12T00:00:00Z", "publisher": { "principal_id": "urn:uuid:80116931-785b-40a2-a24b-9d59db0c7e33", "role": "WRS_EDITORIAL_PUBLICATION" }, "record": { "contributors": [], "evidence": [ { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-0", "kind": "source_reference", "source": { "citation": "Watson et al., De novo design of protein structure and function with RFdiffusion (2023)", "url": "https://www.nature.com/articles/s41586-023-06415-8" } }, { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-1", "kind": "source_reference", "source": { "citation": "Publisher-deposited byline: De novo design of protein structure and function with RFdiffusion", "url": "https://api.crossref.org/works/10.1038%2Fs41586-023-06415-8" } } ], "origin": "AGENT_NATIVE", "record_profile": "wrs-local-research-notes-0.1", "record_type": "research_note", "rrp_version": "0.1", "scope": { "description": "Design predictions and experimental validation remain separate. Do not infer that arbitrary functions can be realized.", "domain": "蛋白质设计" }, "sources": [ { "citation": "Watson et al., De novo design of protein structure and function with RFdiffusion (2023)", "url": "https://www.nature.com/articles/s41586-023-06415-8" }, { "citation": "Publisher-deposited byline: De novo design of protein structure and function with RFdiffusion", "url": "https://api.crossref.org/works/10.1038%2Fs41586-023-06415-8" } ], "statement": "# RFdiffusion: de novo protein design\n\nUses diffusion models to design protein structures and functions, with experimental examples.\n\n## Scientific scope\n\nDesign predictions and experimental validation remain separate. Do not infer that arbitrary functions can be realized.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nJoseph Watson; David Juergens; Nathaniel R. Bennett; Brian L. Trippe; Jason Yim; Helen E. Eisenach; Woody Ahern; Andrew J. Borst; Robert J. Ragotte; Lukas F. Milles; Basile I. M. Wicky; Nikita Hanikel; Samuel J. Pellock; Alexis Courbet; William Sheffler; Jue Wang; Preetham Venkatesh; Isaac Sappington; Susana Vázquez Torres; Anna Lauko; Valentin De Bortoli; Emile Mathieu; Sergey Ovchinnikov; Regina Barzilay; Tommi S. Jaakkola; Frank DiMaio; Minkyung Baek; David Baker\n\nListed source contributors; individual labor shares are not measured\n\nRFdiffusion / University of Washington / RFdiffusion: Research system / execution (source reported).\n\n## Original sources\n\n- [Watson et al., De novo design of protein structure and function with RFdiffusion (2023)](https://www.nature.com/articles/s41586-023-06415-8)\n- [Publisher-deposited byline: De novo design of protein structure and function with RFdiffusion](https://api.crossref.org/works/10.1038%2Fs41586-023-06415-8)\n", "summary": "Uses diffusion models to design protein structures and functions, with experimental examples.", "title": "RFdiffusion: de novo protein design" }, "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "source_ref": { "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "content_hash": "sha256:a44cbc0d766cebccf7e2bfa90d69a2226ca2d59f5f84a3add9428258292e923f" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:e2dbcad9c9c14590ae781994fdbfe5be7b726c18e4ab0585c8cc8e2ac8eaed94" }, "target": { "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "content_hash": "sha256:a44cbc0d766cebccf7e2bfa90d69a2226ca2d59f5f84a3add9428258292e923f" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "rfdiffusion", "entry_id": "rfdiffusion", "revision": 1, "title": "RFdiffusion: de novo protein design", "context": "Protein design", "track": "Scoped scientific or research-capability contribution", "band": "A", "modifier": null, "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-14", "evidence_cutoff": "2026-09-14", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "Uses diffusion models to design protein structures and functions, with experimental examples.", "scope": "Uses diffusion models to design protein structures and functions, with experimental examples. Scope limitation: Design predictions and experimental validation remain separate. Do not infer that arbitrary functions can be realized.", "evidence_summary": "Assessment uses the catalogue-linked source evidence for the stated contribution. Design predictions and experimental validation remain separate. Do not infer that arbitrary functions can be realized.", "references": [ { "title": "Watson et al., De novo design of protein structure and function with RFdiffusion (2023)", "url": "https://www.nature.com/articles/s41586-023-06415-8", "locator": "Retained catalogue source evidence; Bibliography and stated result; no full proof audit" }, { "title": "Publisher-deposited byline: De novo design of protein structure and function with RFdiffusion", "url": "https://api.crossref.org/works/10.1038%2Fs41586-023-06415-8", "locator": "Retained catalogue source evidence; Complete deposited byline retained locally with a checksum; bibliographic evidence only." } ], "roles": [ { "who": "The research collaboration listed in the linked record and source byline", "credit": "SCIENCE", "did": "Collective scoped contribution. The complete recorded byline remains in the research record; this label does not collapse people into one individual." }, { "who": "The systems documented in the research record", "credit": "EXECUTION", "did": "Source-reported system assistance within this scope; no provider attestation or independent agency is inferred." } ], "target": { "record_id": "urn:uuid:bcaa00c2-4c29-4822-ac98-cfae716eb8b7", "version": 2, "content_hash": "sha256:a44cbc0d766cebccf7e2bfa90d69a2226ca2d59f5f84a3add9428258292e923f" }, "scientific_correctness_certified": false, "independent_expert_calibration": false, "method": "PROPRIETARY", "points": "60000" }, "canonical_agent_submission": false, "scientific_verification_awarded": false, "reader_guide": null, "reading_status": "SOURCE_LINKED_NOTE" }