CRISPR–Cas9: a programmable RNA-guided nuclease

What is recorded here?

Establishes an experimental mechanism for programmable RNA-guided DNA cleavage by Cas9.

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Scientific scope

This entry covers the 2012 mechanism paper. Earlier CRISPR discoveries, later cellular editing and applications are not absorbed into this one record.

Read the original work

Jinek et al., A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity (2012)

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People and systems

Martin Jinek; Krzysztof Chylinski; Ines Fonfara; Michael Hauer; Jennifer Doudna; Emmanuelle Charpentier

Listed source contributors; individual labor shares are not measured

Research locations and affiliations

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Documented countries / regions: United States, Austria, Sweden

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Attribution source

English catalogue narrative