AWhat changed
Positional cloning identified the mouse obese gene and its human homologue and supported a model in which its product participates in signalling from adipose tissue to regulate body-fat stores.
Scientific scope
The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.
Evidence
The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.
Contributors
- Yiying Zhang · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Ricardo Proenca · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Margherita Maffei · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Marisa Barone · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Lori Leopold · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Jeffrey M. Friedman · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Nature record for positional cloning of the obese gene
- Crossref record for positional cloning of the obese gene
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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