Tang et al.: whole-transcriptome mRNA sequencing from a single cell

What changed

Individual-cell transcriptomes became directly sequenceable at broad gene coverage in the demonstrated setting.

Scientific scope

The 2009 single-cell experiment; later droplet-scale throughput, spatial omics and every single-cell assay are excluded.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. This is the 2009 single-blastomere method paper, not the origin of every single-cell assay or the later high-throughput field.

Contributors

• The named authors listed in the linked research record · SCIENCE: Complete source byline retained in the research record; this collective display does not merge person identities or measure labor shares.

• Tang et al., mRNA-Seq whole-transcriptome analysis of a single cell (2009)

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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