Szmuness and colleagues: controlled hepatitis-B vaccine efficacy trial

What changed

Protection against hepatitis B was demonstrated in a rigorous human trial.

Scientific scope

Exact nine-author 1980 NEJM trial, preparation, participants and follow-up; recombinant vaccine and universal programs excluded.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1980 NEJM trial, population, vaccine preparation and follow-up. Recombinant hepatitis-B vaccines, universal immunization programmes, later safety surveillance and hepatitis elimination remain separate.

Contributors

Wolf Szmuness · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Cladd E. Stevens · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Edward J. Harley · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Edith A. Zang · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
William R. Oleszko · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Daniel C. William · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Richard Sadovsky · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
John M. Morrison · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
Aaron Kellner · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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