Smith & Wilcox: a precise tool for cutting DNA

What changed

Purified and characterized a restriction enzyme from Haemophilus influenzae, enabling controlled cleavage of DNA.

Scientific scope

Purified and characterized a restriction enzyme from Haemophilus influenzae, enabling controlled cleavage of DNA. Scope limitation: This is the purification and properties paper. Recognition-site analysis and later recombinant-DNA construction are related but distinct contributions.

Evidence

Assessment uses the catalogue-linked source evidence for the stated contribution. This is the purification and properties paper. Recognition-site analysis and later recombinant-DNA construction are related but distinct contributions.

Contributors

• Hamilton O. Smith · SCIENCE: Named source contributor; exact labor shares are not measured.
• K.W. Welcox · SCIENCE: Named source contributor; exact labor shares are not measured.

• A Restriction enzyme from Hemophilus influenzae
• A Restriction enzyme from Hemophilus influenzae — deposited bibliography

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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