Cohen and collaborators: building functional recombinant DNA

What changed

Joined DNA fragments into plasmids that replicated and expressed inherited properties after introduction into bacteria.

Scientific scope

Joined DNA fragments into plasmids that replicated and expressed inherited properties after introduction into bacteria. Scope limitation: The reported plasmid construction is not sole credit for genetic engineering or for every later biotechnology product.

Evidence

Assessment uses the catalogue-linked source evidence for the stated contribution. The reported plasmid construction is not sole credit for genetic engineering or for every later biotechnology product.

Contributors

• Stanley N. Cohen · SCIENCE: Named source contributor; exact labor shares are not measured.
• Annie C. Y. Chang · SCIENCE: Named source contributor; exact labor shares are not measured.
• Herbert W. Boyer · SCIENCE: Named source contributor; exact labor shares are not measured.
• Robert B. Helling · SCIENCE: Named source contributor; exact labor shares are not measured.

• Construction of Biologically Functional Bacterial Plasmids In Vitro
• Construction of Biologically Functional Bacterial Plasmids In Vitro — deposited bibliography

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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