AWhat changed
Demonstrated enzymatic amplification of human beta-globin genomic sequences followed by restriction-site analysis.
Scientific scope
The 1985 enzymatic amplification and beta-globin analysis described by Saiki and colleagues.
Evidence
Original sources and institutional historical accounts support the stated contribution. The reading boundary is recorded at each source; this assessment is not an independent scientific verification.
Contributors
- Randall K. Saiki · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Stephen Scharf · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Fred Faloona · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Kary B. Mullis · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Glenn T. Horn · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Henry A. Erlich · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Norman Arnheim · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
- Saiki et al., Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia, Science 230, 1350–1354 (1985)
- Saiki et al. (1985), university-hosted original Science paper
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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