Palermo and colleagues: pregnancies after intracytoplasmic sperm injection

What changed

Reported fertilization, embryo transfer, pregnancies and live births after direct intracytoplasmic injection of a single spermatozoon in couples with severe male-factor infertility and prior assisted-fertilization failure.

Scientific scope

The record is the exact 1992 Lancet report and the outcomes it describes. Broader ICSI efficacy, safety, later protocols and subsequent clinical uptake remain separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1992 Lancet report and the outcomes it describes. Broader ICSI efficacy, safety, later protocols and subsequent clinical uptake remain separate.

Contributors

• Gianpiero Palermo · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Hubert Joris · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Paul Devroey · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• André C. Van Steirteghem · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for the first ICSI pregnancies report
• Crossref record for the ICSI pregnancies report

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

Full scientific record · Browse contribution grades · Request a correction