BWhat changed
Researchers used protein language models to propose CRISPR-associated proteins and experimentally tested generated editors. The study reports functional genome editing with OpenCRISPR-1 and compatibility with base editing.
Scientific scope
Researchers used protein language models to propose CRISPR-associated proteins and experimentally tested generated editors. The study reports functional genome editing with OpenCRISPR-1 and compatibility with base editing. Scope limitation: AI proposed molecular designs; human teams selected, constructed and tested them. Results concern the studied cellular experiments and do not establish clinical safety, therapeutic benefit or universal superiority over natural editors. This is one study-level package, not one achievement per generated sequence.
Evidence
The retained primary-source abstract, bibliographic record and stated review scope support this provisional assessment. No independent experimental replication by WRS is claimed. AI proposed molecular designs; human teams selected, constructed and tested them. Results concern the studied cellular experiments and do not establish clinical safety, therapeutic benefit or universal superiority over natural editors. This is one study-level package, not one achievement per generated sequence.
Contributors
- The named authors listed in the linked research record · SCIENCE: Complete source byline retained in the research record; human research direction, method development and evaluation. Individual labor shares are not measured.
- The systems documented in the research record · EXECUTION: Source-reported prediction or molecular generation within the stated scope; human testing and interpretation remain separately attributed.
- Design of highly functional genome editors by modelling CRISPR–Cas sequences
- Design of highly functional genome editors by modelling CRISPR–Cas sequences — author abstract and complete deposited byline
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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