Ondetti, Rubin and Cushman: orally active ACE inhibitors

What changed

Model-guided small-molecule ACE inhibitors showed oral activity and blood-pressure lowering in rats.

Scientific scope

The record is the exact 1977 Science paper and its preclinical experiments. Earlier venom peptides, subsequent human captopril trials, regulatory approval, other ACE inhibitors and population-level outcome claims remain separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1977 Science paper and its preclinical experiments. Earlier venom peptides, subsequent human captopril trials, regulatory approval, other ACE inhibitors and population-level outcome claims remain separate.

Contributors

• Miguel A. Ondetti · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Bernard Rubin · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• David W. Cushman · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for orally active ACE inhibitors
• Crossref record for orally active ACE inhibitors

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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