Modified RNA and innate immune recognition

What changed

Reported that incorporating selected modified nucleosides reduced RNA-triggered Toll-like-receptor activity and dendritic-cell activation in the tested cellular systems.

Scientific scope

The 2005 cellular findings on modified nucleosides and RNA-triggered innate immune recognition.

Evidence

Original sources and institutional historical accounts support the stated contribution. The reading boundary is recorded at each source; this assessment is not an independent scientific verification.

Contributors

• Katalin Karikó · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
• Michael Buckstein · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
• Houping Ni · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.
• Drew Weissman · SCIENCE: Named source contributor to this scoped work; individual labor shares are not measured.

• Karikó et al., Suppression of RNA Recognition by Toll-Like Receptors, Immunity 23(2), 165–175 (2005); DOI 10.1016/j.immuni.2005.06.008

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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