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Mayberg and colleagues: deep brain stimulation for treatment-resistant depression

Contribution grade

Neuroscience and psychiatry · METHOD

Reference score80,000Provisional editorial estimate of this exact contribution; its grade is assessed separately.

What changed

Reported six selected patients receiving subgenual-cingulate stimulation with clinical and blood-flow observations.

Scientific scope

The record is the exact eight-author 2005 study. It is a small uncontrolled pilot in a selected refractory population; it does not establish general efficacy, comparative effectiveness, long-term safety or applicability to other targets and disorders.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact eight-author 2005 study. It is a small uncontrolled pilot in a selected refractory population; it does not establish general efficacy, comparative effectiveness, long-term safety or applicability to other targets and disorders.

Contributors

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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