Marshall and colleagues: attempted Koch-postulate test for pyloric Campylobacter

What changed

Reported self-inoculation, bacterial colonization and histologically verified acute gastritis in one volunteer.

Scientific scope

The record is the exact four-author 1985 report and one-volunteer experiment. It supports bacterial causation of acute gastritis under the reported conditions, not that every ulcer has one cause or that all Koch postulates for chronic ulcer disease were established.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact four-author 1985 report and one-volunteer experiment. It supports bacterial causation of acute gastritis under the reported conditions, not that every ulcer has one cause or that all Koch postulates for chronic ulcer disease were established.

Contributors

• Barry J. Marshall · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• John A. Armstrong · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• David B. McGechie · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Ross J. Glancy · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• PubMed record for pyloric Campylobacter self-inoculation report
• McGill-hosted authorized reproduction of Marshall paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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