Ritchie and colleagues: limma for RNA-seq and microarray studies

What changed

A shared package workflow covered microarrays and RNA-seq with broader downstream analyses.

Scientific scope

The exact seven-author 2015 paper and identifiable contemporary enhancements, not the original invention of limma or voom.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact seven-author 2015 paper and the package features and recent enhancements it documents. Earlier limma and voom papers, later releases, other Bioconductor packages and downstream discoveries remain separate.

Contributors

• Matthew E. Ritchie · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Belinda Phipson · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Di Wu · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Yifang Hu · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Charity W. Law · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Wei Shi · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Gordon K. Smyth · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• Ritchie et al., limma powers differential expression analyses
• Crossref record for limma 2015

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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