Hench and colleagues: compound E and ACTH in rheumatoid arthritis

What changed

Reported early compound E and ACTH responses in rheumatoid arthritis patients.

Scientific scope

The record is the exact four-author 1949 Mayo Clinic proceedings report. It is an early uncontrolled clinical series, not randomized evidence of long-term efficacy or safety, and does not absorb steroid chemistry, later trials or other indications.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact four-author 1949 Mayo Clinic proceedings report. It is an early uncontrolled clinical series, not randomized evidence of long-term efficacy or safety, and does not absorb steroid chemistry, later trials or other indications.

Contributors

• Philip S. Hench · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Edward C. Kendall · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Charles H. Slocumb · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Howard F. Polley · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• Hench and colleagues: compound E and ACTH in rheumatoid arthritis

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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