BWhat changed
Routine measured lipids could yield an LDL estimate without ultracentrifugation in suitable samples.
Scientific scope
1972 three-author paper and studied conditions; later replacement equations and universal clinical validity excluded.
Evidence
The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact three-author 1972 paper and the populations and conditions it reports. The equation has known limitations for high triglycerides, low LDL cholesterol and nonfasting samples; later replacement equations are separate.
Contributors
- William T. Friedewald · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Robert I. Levy · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Donald S. Fredrickson · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Friedewald, Levy and Fredrickson, Estimation of LDL cholesterol
- Crossref record for Friedewald LDL estimation
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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