AWhat changed
A pharmacologic intervention produced observed temporary remissions in an otherwise severe disease.
Scientific scope
1948 five-author report; not durable cure, randomized efficacy or all later combination chemotherapy.
Evidence
The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. This is the 1948 five-author report of a small uncontrolled series and temporary remissions, not proof of durable cure or a claim that one paper created all cancer chemotherapy.
Contributors
- Sidney Farber · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Louis K. Diamond · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Robert D. Mercer · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Robert F. Sylvester Jr. · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- James A. Wolff · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- Farber et al., Temporary Remissions in Acute Leukemia in Children Produced by Aminopterin
- Review of the first complete remissions in childhood leukemia with aminopterin
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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