Endo, Kuroda and Tsujita: compactin inhibits cholesterol synthesis

What changed

A fungal compound offered a concrete route to experimentally suppress cholesterol synthesis.

Scientific scope

The 1976 discovery paper; later target-mechanism paper, safety, human treatment and other statins are excluded.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record does not claim clinical effectiveness, the later enzyme-mechanism paper, statin development as a whole or downstream trials.

Contributors

• Akira Endo · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Masao Kuroda · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Yoshio Tsujita · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• Endo, Kuroda and Tsujita, ML-236A, B and C (1976)

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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