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Meselson & Stahl: testing how DNA copies itself

Contribution grade

Life & medicine · Scoped scientific or research-capability contribution

Reference score110,000Provisional editorial estimate of this exact contribution; its grade is assessed separately.

What changed

Used isotope labelling and density separation to distinguish semiconservative DNA replication from competing models in E. coli.

Scientific scope

Used isotope labelling and density separation to distinguish semiconservative DNA replication from competing models in E. coli. Scope limitation: The result concerns the tested biological system and generations. The experiment is distinct from the earlier double-helix proposal.

Evidence

Assessment uses the catalogue-linked source evidence for the stated contribution. The result concerns the tested biological system and generations. The experiment is distinct from the earlier double-helix proposal.

Contributors

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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