Cotzias, Papavasiliou and Gellene: chronic L-Dopa treatment of Parkinsonism

What changed

Documented substantial symptomatic response under slowly escalated chronic oral L-Dopa in 28 patients.

Scientific scope

The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.

Contributors

• George C. Cotzias · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Paul S. Papavasiliou · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Rosemary Gellene · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• NEJM L-Dopa paper
• PubMed record for chronic L-Dopa treatment

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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