AWhat changed
Proposed antigen selection and expansion of pre-existing lymphocyte clones to explain antibody specificity and memory.
Scientific scope
The record is Burnet's sole-author 1957 Australian Journal of Science paper. It is a theoretical proposal that builds on Jerne and contemporary ideas; later experimental support, Burnet's 1959 book and modern B- and T-cell mechanisms remain separate.
Evidence
The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is Burnet's sole-author 1957 Australian Journal of Science paper. It is a theoretical proposal that builds on Jerne and contemporary ideas; later experimental support, Burnet's 1959 book and modern B- and T-cell mechanisms remain separate.
Contributors
- F. M. Burnet · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
- WEHI repository record for Burnet clonal-selection paper
- Nature Immunology reprint and history of clonal selection
Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.
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