Blumberg, Alter and Visnich: a new antigen in leukemia sera

What changed

Reported the serum antigen system later recognized as Australia antigen.

Scientific scope

The record is the exact three-author 1965 JAMA paper. The paper did not yet establish that the antigen was hepatitis B surface antigen, prove viral causation or demonstrate a vaccine; those later identifications and applications remain separate.

Evidence

The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact three-author 1965 JAMA paper. The paper did not yet establish that the antigen was hepatitis B surface antigen, prove viral causation or demonstrate a vaccine; those later identifications and applications remain separate.

Contributors

• Baruch S. Blumberg · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Harvey J. Alter · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.
• Sam Visnich · SCIENCE: Named source author of the scoped work; individual effort shares are not measured.

• JAMA page for A New Antigen in Leukemia Sera
• University-hosted citation retrospective for Australia antigen paper

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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