AlphaFold 2: protein structure prediction

What changed

A learned prediction system substantially improved the accuracy of many protein-structure predictions.

Scientific scope

The AlphaFold 2 method and CASP14 predictive performance described in the 2021 paper.

Evidence

The cited historical record or published author account supports this scoped contribution. The source-reading boundary is stated at each link; a WRS grade is not an independent scientific validation.

Contributors

• Jumper and the full recorded paper team · SCIENCE: Method development, evaluation and research design; byline retained.
• AlphaFold 2 · EXECUTION: AI inference producing predicted structures; source-reported system role.
• Experimental structural-biology community · INFRASTRUCTURE: Curated sequence and structural resources underlying the work.

• AlphaFold 2 original abstract
• AlphaFold 2 published article

Provisional WRS assessment, edition 2026-10-16.1. Independent expert calibration is pending. This grade does not certify correctness or assign ownership.

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