What is recorded here?
Used electrophoretic behavior to distinguish normal, sickle-cell-disease and sickle-cell-trait hemoglobin preparations, supporting a molecular difference in hemoglobin associated with the disease.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The record is the exact four-author November 1949 Science paper. It does not claim that the causal amino-acid substitution was identified in this work, absorb inheritance studies or establish modern diagnosis and treatment. PubMed exposes only two names and marks its list incomplete; Caltech and Crossref preserve all four.
Read the original work
- CaltechAUTHORS record for sickle-cell molecular-disease paper
- Crossref metadata for sickle-cell paper
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People and systems
Linus Pauling; Harvey A. Itano; S. J. Singer; Ibert C. Wells
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.
Research locations and affiliations
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Documented countries / regions: United States
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English catalogue narrative
Pauling, Itano, Singer and Wells: sickle-cell anemia as a molecular disease
Used electrophoretic behavior to distinguish normal, sickle-cell-disease and sickle-cell-trait hemoglobin preparations, supporting a molecular difference in hemoglobin associated with the disease.
Scientific scope
The record is the exact four-author November 1949 Science paper. It does not claim that the causal amino-acid substitution was identified in this work, absorb inheritance studies or establish modern diagnosis and treatment. PubMed exposes only two names and marks its list incomplete; Caltech and Crossref preserve all four.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Linus Pauling; Harvey A. Itano; S. J. Singer; Ibert C. Wells
The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.