What is recorded here?
ESM3 generated protein candidates conditioned on sequence, structure and function. Human laboratory testing identified a bright fluorescent protein with substantial sequence differences from known fluorescent proteins.
Source-linked catalogue note. A detailed explanatory guide has not yet been prepared for this entry.
Scientific scope
The 2025 paper follows a 2024 preprint. The evolutionary-timescale analogy in its title is an estimate, not a literal simulation or experimentally observed evolutionary history. Generation, human selection and wet-lab validation are separate contributions; this does not establish general success across protein functions.
Read the original work
- Simulating 500 million years of evolution with a language model
- Simulating 500 million years of evolution with a language model — author abstract and complete deposited byline
This English explanation is an editorial reading view. It does not replace the complete original work or certify its science.
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People and systems
Thomas Hayes; Roshan Rao; Halil Akin; Nicholas J Sofroniew; Deniz Oktay; Zeming Lin; Robert Verkuil; Vincent Q Tran; Jonathan Deaton; Marius Wiggert; Rohil Badkundri; Irhum Shafkat; Jun Gong; Alexander Derry; Raul S Molina; Neil Thomas; Yousuf A Khan; Chetan Mishra; Carolyn Kim; Liam J Bartie; Matthew Nemeth; Patrick D Hsu; Tom Sercu; Salvatore Candido; Alexander Rives
Complete named paper byline. Human research, source-reported system execution and experimental validation are distinct; individual effort shares are not measured.
ESM3 · EvolutionaryScale · ESM3 (published study)
Generated fluorescent-protein candidates; human researchers selected and experimentally tested them. Source-reported attribution; provider attestation is unavailable.
Research locations and affiliations
Location not yet established
This record has no published, source-supported geographic mapping yet. Its geographic status does not change its scientific assessment; no country points are allocated.
English catalogue narrative
ESM3: generating a fluorescent protein with laboratory-confirmed function
ESM3 generated protein candidates conditioned on sequence, structure and function. Human laboratory testing identified a bright fluorescent protein with substantial sequence differences from known fluorescent proteins.
Scientific scope
The 2025 paper follows a 2024 preprint. The evolutionary-timescale analogy in its title is an estimate, not a literal simulation or experimentally observed evolutionary history. Generation, human selection and wet-lab validation are separate contributions; this does not establish general success across protein functions.
Reading status
This is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.
People and systems
Thomas Hayes; Roshan Rao; Halil Akin; Nicholas J Sofroniew; Deniz Oktay; Zeming Lin; Robert Verkuil; Vincent Q Tran; Jonathan Deaton; Marius Wiggert; Rohil Badkundri; Irhum Shafkat; Jun Gong; Alexander Derry; Raul S Molina; Neil Thomas; Yousuf A Khan; Chetan Mishra; Carolyn Kim; Liam J Bartie; Matthew Nemeth; Patrick D Hsu; Tom Sercu; Salvatore Candido; Alexander Rives
Complete named paper byline. Human research, source-reported system execution and experimental validation are distinct; individual effort shares are not measured.
ESM3 / EvolutionaryScale / ESM3 (published study): Generated fluorescent-protein candidates; human researchers selected and experimentally tested them (source reported).